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Core shell copper2/18/2023 ![]() ![]() Antibacterial study clearly shows that C-S CuSiO2NP is more effective than insoluble Cu hydroxide particles at equivalent metallic Cu concentration, suggesting improvement of Cu bioavailability (i.e., more soluble Cu) in C-SCuSiO2NP material due to its core-shell design. Bac-light fluorescence microscopy based assay was used to count relative population of the live and dead bacteria cells. The estimated MIC values were 2.4 microg metallic Cu/mL for both E. Bacterial growth in solution was measured against different concentrations of C-S CuSiO2NP to determine the Minimum Inhibitory Concentration (MIC) value. We have established a cooperative reaction mechanism where both the copper oxide shell and copper core are required for the chemisorption of HCN onto copper. subtilis using Cu hydroxide ("Insoluble" Cu compound, sub-micron size particles) as positive control and silica "seed" particles (without Cu loading) as negative control. Antibacterial efficacy of C-S CuSiO2NP was evaluated against E. The Cu loading was estimated to be 0.098 microg of metallic copper per mg of C-S CuSiO2NP material by the AAS technique. Loading of Cu to nanoparticles was confirmed by the SEM-Energy Dispersive X-Ray Spectroscopy (EDS) and Atomic Absorption Spectroscopy (AAS). Characterization of particle size distribution in solution by Dynamic Light Scattering (DLS) technique was fairly consistent with the electron microscopy results. The SEM particle characterization confirms formation of highly monodispersed particles with smooth surface morphology. The Scanning Electron Microscopy (SEM) and the Transmission Electron Microscopy (TEM) measured the seed particle size to be -380 nm and the shell thickness to be -35 nm. of the NPs were (100 10) nm and (820 157) Kd, respectively the particles were crystalline in nature and 90 of the precursors Cu(NO 3) 2 and AgNO 3 were converted to the NPs. Synthesis of the core-shell Cu-silica nanoparticle (C-S CuSiO2NP) involves preparation of base-hydrolyzed Stöber silica "seed" particles first, followed by the acid-catalyzed seeded growth of the Cu-silica shell layer around the core. The round-shaped particles were of a core-shell structure with a core of Cu 0 atoms surrounded by a shell of Ag 0 atoms. We report synthesis of a novel core-shell silica based antimicrobial nanoparticles where the silica shell has been engineered to accommodate copper (Cu). ![]()
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